Why do you need to perform 3D cell cultures ?

Human tissue is composed of proteins and polysaccharides such as collagen, which forms the extracellular matrix (ECM).This structure provides a complex microenvironment for cells in tissues.  In this environment, cell-cell and cell-extracellular matrix interactions take place and the extracellular matrix not only stores and supplies biochemical factors but it also provides a physical environment for cell growth.

Conventional two-dimensional cell cultures are performed on a flat environment that is different from the extracellular matrix.

In this environment, which is different from the human body, cells grow in stretched forms on a surface instead of in an oval form as it does in in vivo growth. Such cell growth has the limit that creates a cell-cell environment that is different from physiological conditions.

Nanofibers provide an environment similar to an in vitro matrix, providing an optimal 3D cell culture environment. This is an ideal way to create the 3D culture environment, wherein porosity and a high surface area-to-volume ratio are copied from the in vitro matrix. 3D cell culture, as the only alternative that can substitute for animal testing, can be utilized for various applications.  

HepG2 cells on NANOFIBERS
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NIH3T3 cells on NANOFIBERS
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C2c12 cells on NANOFIBERS
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C2c12 cells onNANOFIBERS
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ARTIPORE (3D cell culture product)

As Korea’s first products made by combining electrospinning (nanofibers) and 3D printing (patterning) technologies, ARTIPORE products overcome the limitations of 2D cell cultures by realizing an environment similar to the extracellular matrix (ECM) of the human body.

We manufacture products to which biocompatible materials are applied, including PCL and collagen approved by the FDA.

ST1’s own brand,“ARTIPORE“ nanofibers, ensure the highest quality based on high porosity and batch-to batch consistency. The properties of several nanofibers can be selected according to experiment purposes, and the nanofibers to which the frame is applied especially provide a more convenient experimental environment due to their easy mobility during the experiment.    

ARTIPORE 3D cell culture product

Alternatives to animal testing

Animal testing aims to confirm the safety and effectiveness of newly developed medicines, medical supplies, medical appliances, chemicals, and food before their human application.  The results can then be applied to humans.

Animal testing is essential in the development of medicines but it requires fastidious care and enough time in creating the right environment. It also leads to the unneccessary sacrifice of numerous animals.  

A 3D cell culture experiment can be performed in an environment similar to the human body as it is copied from the body’s ECM. This enables similar inferences to be made about effects and phenomena from a drug’s application in the human body through effective experiments in restricted time periods and environments.  

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